Effects of Composite Probiotics on the Gastrointestinal and Immune Function of Spleen Deficiency Syndrome Rats
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Abstract:
ELISA kit was used to investigate the regulatory effects of different doses of composite probiotics and Sinijunzi Decoction on the levels of serum gastrointestinal hormones and immune factors in spleen deficiency syndrome rats induced by Folium Sennae. The results showed that both composite probiotics and the Sijunzi Decoction could significantly reduce the serum levels of vasoactive intestinal peptide (VIP) and malondialdehyde (MDA) (p < 0.05), while increase the interleukin-2 (IL-2) level in spleen deficiency syndrome rats (p < 0.05). The composite probiotics could also significantly reduce the levels of serum cholecystokinin (CCK), substance P (SP) and interleukin-4 (IL-4) in spleen deficiency rats (p < 0.05), while the Sijunzi Decoction had no significant effect. In addition, the Sijunzi Decoction could significantly decrease the content of serum gastrin (GAS) and motilin (MTL) in spleen deficiency rats (p < 0.01). The results showed that composite probiotics could regulate the levels of gastrointestinal hormone, as well as correcting immune dysfunction of spleen deficiency rats. Compared with the traditional prescription (Sijizitang decoction) for the treatment of spleen deficiency syndrome, the probiotics and Sijunzi decoction had different indicators of gastrointestinal hormones and immune factors, suggesting that the mechanisms of composite probiotics and the Sijunzi Decoction treating on spleen deficiency syndrome may be different.
