Preventive Protective Effects of Wild Kiwifruit and Vitamin C on Alcoholic Liver and Brain Injury in Rats
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Abstract:
The preventive protective effects of wild kiwifruit and pure vitamin C on alcoholic liver and brain injury in rats were investigated in this study. 40 male SD rats were randomly divided into four groups: normal group, model group, vitamin C group and wild kiwifruit group. The normal group was given the same amount of normal saline, and other groups were given 56°Red Star Erguotou by gavage to establish the alcoholic liver and brain injury model(8 mL/kg for first week, and 10 mL/kg for the second week once a day). The normal group and the model group were given the common feed. The wild kiwifruit group was fed with 30% concentration of wild kiwifruit, and the vitamin C group was given vitamin C-fortified feed (420 mg/kg). The liver function, liver lipid content and oxidative stress level were measured after two weeks, and pathological changes of liver and brain were observed by HE staining. Results showed that compared with the model group, wild kiwifruit and vitamin C could significantly reduce alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride(TG), total cholesterol (TC), lipid peroxidation (LPO), malondialdehyde (MDA) in serum, and increase superoxide dismutase(SOD) in serum and brain homogenate (p<0.01). In addition, the decrease and increase indexes were even more significant in wild kiwifruit group (p<0.05). Consequently, wild kiwifruit and vitamin C had preventive protection effects on alcoholic liver and brain injury, and the former had the better effects.
