Effects of Konjac Glucomannan on the Intestinal Physiological Structure and Peristaltic Function in Mice
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Abstract:
Effects of Konjac glucomannan (KGM) on theintestinal physiological structure and peristaltic function in mice were investigated in this study. Modeling human intestinal motility disorders, using sucralfate-modeled young mice (4 weeks old) and old mice (60 weeks old) to explore different doses (low dose:0.18 g/kg and high dose:0.90 g/kg) of KGM on intestinal motility in mice with different ages. After the administration, the defecation time, stool weight, fecal water content, carbon propulsion rates were determined. The results showed that compared with the control group, the high dosage of KGM treatment on sucralfate-treated young and aged mice could significantly prolong the first defecation time and decrease the stool weight. The results of H&E staining showed that the structure integrity of intestinal tissues were destroyed and colonic inflammatory cell aggregation increased in the aged mice treated with high dose of KGM. high dose uptakes of KGM could result in insufficient intestinal motility and the difficulty of defecation in aged people.
