Research Progress of Alcohol Biological Effect Based on Caenorhabditis elegans
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Abstract:
Alcohol is becoming ever more important in modern life, moderate alcohol consumption can promote blood circulation and prevent cardiovascular disease. However, long-term excessive drinking will damage organs, such as liver, stomach and, and even lead to neurological diseases. This phenomenon has become a concerned issue for people. As a special model organism, Caenorhabditis elegans (C.elegans) has relatively simple and clear physiological structures (especially the neural structure), as well as a large number of homologous genes that are confirmed to be related to human disease. Therefore, C.elegans was used as a biological model to study the molecular targets of diseases and related neural pathways. This paper introduces the research progress of life regulation mechanism, neurodegenerative diseases, alcohol-induced addiction and type II diabetes under the condition of alcohol intervention by using Caenorhabditis elegans as a model organism, which shows that C. elegans, as a model organism, has unique advantages in the field of alcohol biological function. The research provides a new method and idea for the prevention and treatment of alcohol related diseases to understand the occurrence and development of alcoholic diseases and the related physiological mechanisms.
