Laxative Function and Acute Toxicity of Danggui Runchang Tea

Abstract:

Three constipation models of spleen and stomach deficiency (SSD) mice (established by ice-water mixture (0~2 oC), yin deficiency and blood stasis (YDBS) mice (established by 2.0 mg/kg hydrocortisone and 150 mg/kg thyroxine ) and gastric slow transit constipation (GSTC) mice (established by 10 mg/kg compound diphenoxylate) were used to investigate the effects of Danggui Runchang tea (DRT) on the first defecation time, defecation within 6 h, fecal water content and peristalic rate of intestinal , and the acute toxicity of DRT was evaluated with maximum tolerance dose. The results showed that the high or medium dose of DRT significantly reduced the first defecation time, and the defecation and peristalic rate of intestinal was increased significantly in SSD mice. For YDBS mice, DRT significantly shortened the first defecation time, and high dose of DRT significantly increased the defecation, fecal water content and peristalic rate of intestinal. In addition, DRT reduced the first defecation time, and increased the defecation, fecal water content and peristalic rate of intestinal significantly in GSTC mice. No acute toxicity reaction was observed on mice by gavage at the highest concentration and maximum administration capacity, which showed that DRT had the laxative function and high oral administration safety.