Evaluation of Cellular Antioxidant and Antiproliferative Activities of Litchi (Litchi chinensis Sonn.) Pulp from Different Cultivars
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Abstract:
The celluar antioxidant activity (CAA) and antiproliferative activitiy of 10 representative litchi (Litchi chinensis Sonn.) cultivars in southern China were evaluated by HepG2 model to investigate the bio-antioxidant and antineoplastic functions of different litchi cultivars in this study. The results showed that Feixixiao had the largest CAA value among the ten litchi cultivars and the Huaizhi was the smallest; Feizixiao had the strongest antiproliferative activity on HepG2 cells and the Nuomici was the weakest. The CAA value of litchi pulp exhibited a significant positive correlation with total polyphenols, total flavonoids and ORAC (oxygen radical absorption capacity) values (p<0.01), and had the highest correlation with total flavonoids, indicating that the main component of biological antioxidants in litchi pulp was flavonoids. However, there was a weak negative correlation between antiproliferative activity of litchi pulp and total polyphenols, total flavonoids, ORAC and CAA values, indicating that some special polyphenol individuals or their synergies played a key role in antiproliferation of tumor cells.
