Inhibitory Effects of Aqueous Extract from Longan (Dimocarpus longan Lour) Leaves on Kidney Calculi
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Abstract:
A rat model of kidney calculi was established by gavage with ethylene glycol and ammonium chloride solution to investigate the inhibitory effects of aqueous extract fromlongan dimocarpus (Lour.) leaves on ethylene glycol-induced kidney calculi in rats. The rats were treated with low, medium and high dose of aqueous extract from longan dimocarpus (Lour.) leaves based on the established model, and the drinking water and urine volume (24 h), urine routine indexes, Serum levels of Cr、BUN、UA、Ca2+、Mg2+ oxalic acid, levels of Ca2+、Mg2+ oxalic acid in kidney tissues were measured. The kidney tissue was subjected to analysis of pathological changes and crystallization The results revealed that each dose of aqueous extract from longan leaves significantly decreased the water volume (p < 0.05) and oxalic acid levels of urine in 24 h, and the high-dose group had a significant difference (p < 0.05). There was a significant decrease of uric acid (UA), blood urea nitrogen (BUN) and creatinine (Cr) in serum and the concentration of Mg2+ in kidney in each dose group, and the effects of aqueous extract in each dose on the concentration of Ca2+and Mg2+ in serum were not significant.. In addition, each dose of aqueous extract from longan leaves could decrease the kidney coefficient and kidney oxalic acid level, and reduce the apoptosis of renal tubular epithelial cell and crystallization degree of oxalic acid, which resulted in the improvement of kidney disease and the reduction of kidney calculi. The results showed that the aqueous extract from longan dimocarpus (Lour.) leaves could inhibit the occurrence of kidney calculi.
