Protective Effect of Bornlisy on Murine Alcoholic-induced Liver Injury and Mechanisms Exploring
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Abstract:
In order to investigate the protective effect of probiotics compound preparations Bornlisy (BO) on murine alcoholic-induced liver injury and explore the underlying mechanisms, acute and chronic alcoholic liver injuries models were establishedin mice by gavage with different concentrations of liquor. Compared with the model group, the survival rate of acute alcoholic liver injury mice with BO treatment was significantly improved (p<0.05), while there was no such effect in BO supernatant treatment group. In chronic alcoholic liver injury model, BO could significantly reduce the increase of liver index and improve fatty pathological injuries and lipid accumulation (p<0.05). Levels of serum ALT and TG decreased significantly (p<0.05), and the activity of liver SOD and GSH-Px increased significantly by 43.30%(p<0.05) and 281.44% in BO treatment group (p<0.01), respectively, while BO supernatant treatment group had no certain effects. Through investigating the fatty acid metabolic pathways, we found that BO treatment could inhibit the decrease of mRNA levels of PPARα, ACOX1 and L-FABP significantly (p<0.05), while BO supernatant treatment had no significant effects (p>0.05). The detection results of SREBP-1c pathway showed that both BO and BO supernatant treatment had no significant effects on SREBP-1c and FAS mRNA expressions. Therefore, BO can protect mice from alcoholic induced liver injuries, which may be achieved by anti-oxidative stress and selectively enhancing PPARα pathway.
