Effects of Bisphenol S Exposure on Behavior and Growth of Caenorhabditis elegans
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Abstract:
Bisphenol S (BPS) has been widely used as a substitute for bisphenol A (BPA) in various products (bottles, food cans, thermal paper, etc.), but there were few studies on toxicology of BPS. In this study, BPS was used as the research object, and Caenorhabditis elegans (C. elegans) was used as model organism to analyze its effect on the motor behavior and growth of C. elegans. The results showed that when the exposure concentration reached 1μM, the frequency of body movement was significantly decreased. And when the exposure concentration reached 10 μM, the thrashing frequency of the head was significantly decreased in the acute toxicity test. With the increase of concentration, BPS also affected the life span and the number of progeny of C. elegans, resulting in shortened life span and fewer brood size. When the concentration of BPS reached 100 μM, the life span decreased by 35.42% and the brood size decreased by 30.47% as compared with the control group; BPS exposure could lead to a significant increase of the reactive oxygen species (ROS) free radicals content in the C. elegans, suggesting that high concentrations of BPS might cause oxidative damage to the C. elegans, and further affect the motor behavioral capacity, life span and the number of offspring.
