The Antioxidant and Antityrosinase Activities of Carvacrol
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The antioxidant and antityrosinase activities of carvacrol was investigated by scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2‘-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), hydroxyl radical (?OH) and superoxide radicals, inhibiting lipid peroxidation and inhibiting tyrosinase activity. The experiment results showed that carvacrol had excellent antioxidant and antityrosinase activities in dose-dependent manner. In the experiments of scavenging DPPH, ABTS, ?OH and superoxide radicals, inhibiting lipid peroxidation and inhibiting tyrosinase activity, the IC50 of carvacrol were 100 μmol/L, 18.18 μmol/L, 16 μmol/L, 16 μmol/L, 12.5 μmol/L and 6.67 μmol/L, respectively. The IC50 of kaempferol used as the positive control drug were 80 μmol/L, 9.09 μmol/L, 12 μmol/L, 12 μmol/L, 8.33 μmol/L and 3.33 μmol/L, respectively. Carvacrol had one phenolic hydroxyl group, while kaempferol had three phenolic hydroxyls. The different molecular structures led to the different antioxidant and antityrosinase activities. In a word, carvacrol had good antioxidant and antityrosinase activities, worth being further researched as the new anti-aging candidate drug, cosmetic materials and food additives.
