Study on Acute Toxicity of Bisphenol A to Caenorhabditis Elegans
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Abstract:
Bisphenol A (BPA) is a ubiquitous endocrine disrupter that can have side effect on human health. In daily life, people are exposed to low concentration of BPA, while the effect of BPA toxicity is not clear at low concentrations. In order to understand the toxic effects of BPA at low concentration, we used Caenorhabditis elegans (C. elegans) as a model organism to study the acute toxicity of low concentration of BPA. The results showed that the LC50 of BPA was 440.16 mg/L for C. elegans, while the low concentration of BPA had significant inhibitory effect on the movement behavior indexes (including head thrashing frequency and body bending frequency) of C. elegans. The most sensitive index was the head thrashing frequency and the lowest concentration was 1 μmol/L. Low concentration of BPA also affected the growth and development of C. elegans as well as the number of progenies. Compared with the control group, BPA at the concentration of 100 μmol/L reduced body length and progeny by 6.05% and 15.24%, respectively. When the concentration of BPA reached 0.01 μmol/L, it could significantly inhibit the life span of C. elegans and increase the level of ROS, causing oxidative stress injury, accelerating the senescence of C. elegans and shortening its life span. In conclusion, low concentration of BPA exposure could affect the movement, growth, reproduction and longevity of C. elegans.
