Chemical Composition, DPPH Free Radical Scavenging and Antimicrobial Activity of the Essential Oil and Six Compounds Isolated from Spiraea mongolica Maxim
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Abstract:
The essential oil was extracted from the dried twigs and leaves of Spiraea mongolica Maxim by hydro-distillation and identified by GC-MS. The main compositions of the oil were fatty acids and their derivatives, ethyl palmitate (38.631%), ethyl linolelaidate (23.576%) and ethyl linolenate (14.634%). From the dried twigs and leaves, botulin (1), lupine-3,20-diol (2), 1β-hydroxyl-6,9-dien-8-oxoeremophil -11-nor-11-ketone (3), 3-(4-Methoxyphenyl) propanal (4), stigmasterol (5), β-Sitosterol (6) were isolated by silica gel column chromatography and identified by NMR data. Their DPPH free radical scavenging and antimicrobial activities were separately evaluated. The essential oil showed good to moderate DPPH free radical scavenging activity (IC50 = 900 μg/mL), while had no apparent antimicrobial activity. Compound (4) exhibited reasonably strong DPPH free radical scavenging ability (IC50 = 13 μg/mL) and showed diverse antimicrobial competence against Aspergillus flavus, Bacillus subtilis and Candida albicans. Compound (3) showed antimicrobial activity against Aspergillus flavus, Bacillus subtilis and weak DPPH free radical scavenging activity. These results of the study had certain significance in the study of traditional Chinese medicine plant and development of new drugs.
