Effects of Purple Sweet Potato Extract on the Lifespan of Caenorhabditis Elegans
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
Effects of Purple sweet potato extract (PSPE) on the lifespan of Caenorhabditis elegans (C. elegans) and its possible mechanism were studied. C. elegans were fed in normal culture medium and NGM culture medium containing different concentrations (70, 140, 280 μg/mL) of PSPE to investigate the effects of PSPE on the lifespan of C. elegans as well as the content of lipofuscin, superoxide dismutase (SOD) and catalase (CAT) and the expressions of antioxidant-related genes in vivo. The Results showed that the average lifespan of C. elegans fed with 280 μg/mL PSPE increased by 33%, the accumulation of lipofuscin decreased by 30%, the activity of SOD and CAT increased by 17.7% and 47.5%, respectively, compared with the blank group. The mRNA levels of daf-16, ctl-1 and sod-3 in nematodes were increased in different degrees, and the mRNA expressions of daf-16, ctl-1 and sod-3 in 280 μg/mL PSPE group were increased by 23.2%, 37.4% and 84.6%, respectively; While the mRNA expression of age-1 in 280 μg/mL PSPE group was decreased by 26.4%.
