Effect of Sea Buckthorn Powder on Hepatic Lipid Metabolism and Oxidative Stress in Rats
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Abstract:
The effects of sea buckthorn powder on the hepatic lipid metabolism and oxidative stress in rats were studied in this paper. Fifty male Wistar rats were randomly divided into five groups: the control group; the high fat/cholesterol diet group; and sea buckthorn powder low-, medium-, and high-dose groups. The control group was fed with basal diet, and other groups were fed with high fat/cholesterol diet during the experiment. The rats in both control and high fat/cholesterol diet groups were given distilled water, and those in low-, medium-, and high-dose treated groups were given sea buckthorn powder at doses of 0.5 mg/g?body weight (bw), 2.5 mg/g?bw, and 5 mg/g?bw, respectively. The animals were sacrificed after four weeks, and livers were collected to measure the liver lipid content, lipid metabolism-related enzyme activity, and oxidative stress level. The results indicated that compared with the high fat/cholesterol diet group, sea buckthorn powder reduced the levels of hepatic total cholesterol (TC), total triglyceride (TG), and malondialdehyde (MDA), and increase the levels of high density lipoprotein-cholesterol (HDL-C) and glutathione (GSH) and the activities of hepatic lipase (HL), lipoprotein lipase (LPL), and total superoxide dismutase (T-SOD). These results demonstrated that sea buckthorn powder could reduce the liver lipid levels, improve lipid metabolism enzyme activities in the liver, increase antioxidant capacity, and slow down lipid peroxidation in hepatocytes of high-fat diet-fed rats.
