Anti-inflammatory Activity of Extract M of Plant Combinations in SD Rats
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Abstract:
Sprague–Dawley (SD) rats were used as the experimental model in this paper whereby an SD rat model of inflammation was established by implanting cotton ball. Further, the effects of extract M of plant combinations on the body weight, food intake, and water intake of rats with cotton-ball-induced inflammation were studied. Enzyme-linked immunosorbent assay (ELISA) was employed to study the effects of extract M of plant combinations on the secretion of inflammatory mediators and synthetic pathways of prostaglandin E2 and leukotriene in rats with cotton-ball-induced inflammation. The results showed that extract M had no significant effects on the body weight, food intake, and water intake of normal SD rats, however had a certain impact on the food intake of rats after the model of inflammation was established. Extract M could significantly alleviate the excessive secretions of C-reactive protein, nitric oxide, arachidonate 5-lipoxygenase, and leukotriene C4 in the inflammation reaction, and had no significant inhibitory effects on the secretions of interleukin-1β, tumor necrosis factor-α, prostaglandin E2, and cyclooxygenase 2. The above findings indicated that extract M of plant combinations exerted anti-inflammatory effects by inhibiting the synthesis of leukotriene C4 by arachidonate 5-lipoxygenase and therefore can contribute to anti-inflammatory applications.
