Research Progress into the Prevention of Osteoporosis Using Flavonoids
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Abstract:
As China is becoming an increasingly aging society, osteoporosis is very common and has become a serious public health and social problem. Decreased bone content in the elderly leads to bone fragility and increases fracture risk, so osteoporosis should be promptly diagnosed. However, the treatment of osteoporosis lags behind that of other chronic illnesses, the clinical phenomenon of early bone lesions is not easy to identify, and the effective prevention of osteoporosis has become an urgent problem to be solved by the medical field. Flavonoids are found widely in vegetables, fruits, and medicinal plants, and have a variety of bioactivities with few side effects. A large number of studies have shown that flavonoids can prevent osteoporosis and protect bone health by promoting osteoblast proliferation and osteocyte mineralization, inhibiting osteoclastic bone resorption, increasing peak bone mass, and reducing bone loss. This article focuses on reviewing research progress into the cellular and molecular mechanisms of action of flavonoids in preventing osteoporosis. This provides a theoretical basis for the development of functional foods and medicines for the prevention of osteoporosis.
