Effects of Short-term Consumption of Fish Oil-egg-phospholipid on Lipid Metabolism in Mice Fed a High-fat Diet
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Abstract:
The effects of short-term consumption of docosahexaenoic acid (DHA)-enriched phospholipids, DHA-enriched triglycerides, and the combination of DHA-enriched triglycerides and egg-phospholipids on lipid metabolism in mice fed a high-fat diet were compared. C57BL/6J mice were divided into five groups: low-fat group, high-fat group, DHA-enriched phospholipid group, DHA-enriched triglyceride group, and DHA-enriched triglyceride-egg-phospholipids combination group. Mice were fed the high-fat diet for a week; thereafter, lipid levels in the serum, liver, and brain were measured, along with the fatty acid compositions in the liver and brain. The short-term dietary supplementation of DHA could improve lipid metabolism in mice to different degrees. The serum triglyceride (TG) concentration was significantly reduced by DHA-enriched phospholipids and by the combination of DHA-enriched triglycerides and egg-phospholipids to the same degree. DHA-enriched phospholipids were superior to the combination of DHA-enriched triglycerides and egg-phospholipids in decreasing total serum cholesterol. The hepatic TG level in the combination group was notably lower than that in the high-fat group. However, no significant difference was observed in the hepatic TG level between the DHA-enriched phospholipids group and the combination group. Furthermore, DHA-enriched phospholipids and the combination of DHA-enriched triglycerides and egg-phospholipids could significantly increase the content of DHA in the liver and brain. DHA-enriched phospholipids could more effectively improve lipid metabolism in the serum and liver of mice fed a high-fat diet, and showed the highest increase in brain DHA level.
