Protective Effects of Areca Inflorescence Tea on Alcohol-induced Hepatic Injury in Rats
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Abstract:
The auxiliary protective effects of areca inflorescence tea on acute alcoholic liver injury were investigated in this study. Fifty SD female rats were randomly divided into five groups, including an ethanol model (control) group, a solvent control group, and low-, medium-, and high-dose areca tea groups. Areca tea was administered by oral gavage to each dose group, while the solvent control group and the ethanol model group were given by gavage. Four hours after gavage, the ethanol model group, and the low-, medium-, and high-dose groups were given 50% ethanol at a dose of 10 mL/kg weight for 30 d, while the solvent control group was given an equal volume of distilled water. The content of alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol (CHO), total bilirubin (TBIL), and low-density lipoprotein (LDL) in serum were then measured, and histopathological examination of liver tissues was also performed. The results showed that the content of AST, ALT, CHO, TBIL, and LDL in the serum were decreased with increasing doses of areca tea, and significant differences were observed between the high dose group and the ethanol model group (p<0.05). The histopathological examination of liver tissues revealed that liver steatosis was mitigated in the high dose group, and the liver pathological scores of the high dose group were significantly lower than those of the model control group (p<0.05). In conclusion, areca inflorescence tea can exert an auxiliary protective effect against acute alcoholic liver injury.
