Effects of Composite Probiotics on Promoting Growth and Development of Young Rats and Improving Their Immune Function
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Abstract:
To explore the effects and mechanism of probiotics on growth, development, and immune function, normal young rats were given low, medium, and high doses of probiotics by gavage for 28 days, and then related indicators of growth, development, and immune function were measured. The results showed that, compared with the negative control group, different doses of probiotics had a growth-promoting effect. The rates of weight gain were increased by 7.56% (low-dose group), 14.45% (medium-dose group), and 1.32% (high-dose group), and food intake was increased by 0.31% (low-dose group), 0.90% (medium-dose group), and 0.13% (high-dose group). Feed-weight ratios were decreased by 3.89% (low-dose group), 3.74% (medium-dose group), and 4.47% (high-dose group). Femur lengths were increased by 1.17% (medium-dose group) and 1.69% (high-dose group), and the activity of α-amylase in the jejunum was increased by 1.48% (low-dose group), 1.28% (medium-dose group), and 1.0% (high-dose group). Thymus indices were increased by 23.65% (low-dose group), 24.68% (medium-dose group), and 25.45% (high-dose group), and liver indices were increased by 0.34% (low-dose group), 6.99% (medium-dose group), and 0.70% (high-dose group). The expression of interleukin-6 (IL-6) in the serum was increased by 5.40% (medium-dose group) and 23.15% (high-dose group). T-lymphocyte transformation rates were increased by 4.55% (low-dose group), 6.50% (medium-dose group), and 12.11% (high-dose group); B lymphocyte transformation rates were increased by 7.90% (low-dose group), 9.64% (medium-dose group), and 13.71% (high-dose group). The expression of tight-junction protein claudin-1 in colonic epithelium was enhanced, and showed a positive correlation with doses. The results indicated that probiotics could increase body weight and femur length by enhancing the activities of intestinal digestive enzymes and promoting the absorption of nutrients. Probiotics could also enhance the expression of IL-6, improve the activities of T-cells and B-cells, and strengthen the expression of tight-junction protein claudin-1 to promote the development and maturation of immune system organs (thymus and liver) and improve immunity.
