Fructo-oligosaccharides Protect Mice against Exhaustive Exercise-induced Dyslipidemia by Modulating Gut Microbial Composition and Function
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Abstract:
To investigate the possible mechanism of fructo-oligosaccharides (FOS) in regulating lipid metabolism, male balb/c mice were randomly divided into three groups: control group (Control), exhaustive exercise group (Motion), and FOS intervention group (FOS). A forced exercise wheel-track treadmill was used in this study, and animals in both Motion and FOS groups were subjected to an exhaustive exercise protocol while the animals in the Control group were kept still. After sixteen days of treatments, the related serum lipid parameters were measured and fecal samples were collected to investigate gut microbiota changes by metagenome. The results showed that the serum total cholesterol content, LDL-C, and HDL-C increased sharply (p<0.05), while the serum triglyceride content decreased significantly (p<0.01). Therefore, exhaustive exercise could be an important factor in lipid metabolism disorders. Our data also showed that a 16-day FOS treatment resulted in a profound change in microbiome structure, which subsequently led to widespread shifts in the gut functional potential. Together, our findings suggest that FOS may protect mice against exhaustive exercise-induced dyslipidemia by modulating gut microbial composition, improving lipid metabolism within microbiota, and regulating enzymes activities involved in fatty acid oxidation and lipid synthesis.
