Research Progress on the Inhibitory Effects of Probiotics on N-nitroso Compound-induced Colon Carcinoma
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
Colon carcinoma, one of the most prevalent malignant tumors, is a serious threat to human health and life. The incidence of colon cancer is a result of the interaction of multiple factors, so there are many difficulties in the prevention and control of colon carcinoma. Currently, numerous drugs are used in the treatment of colon carcinoma, but they all have varying degrees of adverse effects. Therefore, researchers have been working on the development of new, targeted drugs for colon carcinoma without toxic effects. Previous studies have confirmed that fermented foods enriched with probiotic bacteria can decrease the incidence of cancer and have a certain protective effect against colon carcinoma development. Probiotic bacteria exhibited significant anticancer effects in in vitro experiments and also reduced the genotoxicity of carcinogens to colon tissue cells in in vivo animal experiments. N-nitroso compounds have been confirmed as carcinogenic substances that exist widely in processed meat products, and their excessive intake can increase the risk of colon carcinoma. Therefore, this article discusses the effect of probiotic bacteria on the suppression of colon carcinoma development induced by foodborne carcinogens (N-nitroso compounds).
