Protective Effects of Oat Bran Polyphenols in Alloxan-Induced Diabetic Mice
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
Alloxan was used to establish a mouse model of diabetes. The effects of oat bran polyphenols on the general life behavior, body weight, fasting blood glucose, glucose tolerance, serum insulin, and organ indices (liver, kidneys, spleen, and thymus) of diabetic mice were studied. The malondialdehyde (MDA) and glycogen content and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), pyruvate kinase (PK), and hexokinase (HK) in the mouse liver were also recorded. The results indicated that, compared with the model group, the high-dose oat bran polyphenol group (120 mg/kg/d) showed significantly higher body weight, splenic index, thymus index, serum insulin, activities of SOD and HK in the liver, and liver glycogen content, with increases of 21.53%, 53.85%, 54.54%, 31.77%, 48.69%, 42.58%, and 84.05%, respectively. High doses of oat bran polyphenols noticeably reduced the symptoms of excessive drinking, eating, and urinating. In the high-dose oat bran polyphenol group, the fasting blood glucose, blood glucose levels at 0.5 and 1.0 h after glucose tolerance test, the content of MDA in the liver were also decreased significantly by 39.54%, 20.20%, 36.78%, and 35.04%, respectively. Oat bran polyphenols have protective effects in mice with alloxan-induced diabetes.
