Memory Enhancing and Antioxidant Activities of Lycium ruthenicum Murray Anthocyanin Extracts in an Aβ42-Induced Rat Model of Dementia
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Abstract:
Amyloid beta-protein 1-42 (Aβ42) was injected bilaterally into the hippocampal CA1 area of rats to produce an animal model of Alzheimer′s disease (AD), and animal behavior was assessed using the passive-avoidance test in a shuttle box. The activities of total superoxide dismutase (T-SOD) and catalase (CAT), and the contents of glutathione (GSH), malondialdehyde (MDA), and protein carbonyl (PC) in serum and brain tissues were used as evaluation indicators to investigate the effect of Lycium ruthenicum Murray anthocyanin extracts on the in vivo antioxidant activity and memory function of AD model rats. The results showed that the memory capacity of the model group was significantly decreased, while the memory impairment of rats administered Lycium ruthenicum Murray anthocyanin extracts was alleviated. Additionally, the activities of T-SOD and CAT, and the content of GSH in serum and brain tissues were significantly enhanced, whereas MDA and PC contents were decreased in the group that received 80 mg/kg Lycium ruthenicum Murray anthocyanin extracts. Thus, Lycium ruthenicum Murray anthocyanin extracts could enhance memory capacity and antioxidant activities of AD model rats, and had a potential preventive effect against AD.
