Microwave Solid-phase Synthesis Technique and Its Application in the Synthesis of Polypeptide (Amino Acid)-Metal Chelates
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Abstract:
Polypeptide (amino acid)-metal chelates are a new-type metal nutritional supplement with the advantages of high absorption and utilization ratios, low energy consumption during metabolism, and fast transport speed, as well as their inability to be easily saturated. Additionally, polypeptides can serve as metal element ligands to enter intestinal mucosal cells through small peptide transport systems. Polypeptide (amino acid)-metal chelates are highly stable and can reduce the antagonism among metal ions, showing good application prospects. Compared to traditional liquid-phase synthesis, microwave solid-phase synthesis is a new polypeptide (amino acid)-metal complex synthesis technique with the advantages of fast reaction rate, high reaction efficiency, low energy consumption, simple process operation, low level of pollution, and no waste liquid production, and has been utilized widely in the synthesis of polypeptide (amino acid)-metal chelates. In this paper, the principles, applications, and factors affecting microwave solid-phase synthesis of polypeptide (amino acid)-metal chelates and their identification were systematically reviewed. Meanwhile, some suggestions for the development of microwave solid-phase synthesis technique were made, in order to promote the application of the technique in the synthesis of polypeptide (amino acid)-mental chelates.
