Abstract:The hypolipidemic effect of large yellow croaker roe phospholipids was studied using a mouse model of hyperlipidemia. Mice were randomly divided into six groups: model, blank, soybean phospholipid (negative control), and low-dose (5 g/kg), medium-dose (15 g/kg) and high-dose (30 g/kg) large yellow croaker roe phospholipid group. After four weeks of feeding, the pathological changes of liver and phospholipid metabolism indices in the serum were investigated. The results indicated that large yellow croaker roe phospholipids suppressed mouse body weight gain. Compared with model group, medium-dose and high-dose large yellow croaker roe phospholipids significantly reduced levels of total cholesterol (TC), triglycerides (TG), and the values of atherogenic indexes 1 (AI1) and 2 (AI2) (p<0.05), but had no marked impact on levels of low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C). The findings suggest that medium- and high-dose large yellow croaker roe phospholipids regulated lipid metabolism in hyperlipidemic mice. Based on the results of pathological histology of mouse liver, low-dose large yellow croaker roe phospholipid did not show significant effect on hepatocytes (p>0.05), whereas medium- and high-dose large yellow croaker roe phospholipids showed a significant effect on repairing hepatocellular degeneration. The results indicate that large yellow croaker roe phospholipids can prevent fatty degeneration of mouse liver and help reducing the risk of atherosclerosis.
