Neuroprotective Effects of Different Protein Hydrolysates against Oxidative Stress-induced Cytotoxicity in PC12 Cells
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Abstract:
Here, the effects of three protein hydrolysates (cerebrolysin, cod peptide, and walnut peptide) on rat pheochromocytoma (PC12) injured by H2O2 was evaluated. The results showed that addition of H2O2 decreased the number of viable PC12 cells and altered cell morphology, resulting in shrunken circular or oval shapes accompanied by disappearance of the peripheral halo. However, cerebrolysin exhibited the strongest protective effects against H2O2-induced oxidative injury in PC12 cells, followed by walnut peptide, whereas no significant effect was observed in the presence of cod peptide. Additionally, all three hydrolysates supported proliferation and survival of the injured cells. These findings indicated that walnut peptide constituted a potential raw food material capable of improving cerebral dysfunction.
