Heptoprotective Effects of Flavonoids from Buddleja officinalis Maxim. (L.) DC. against CCl4-induced Acute Hepatic Damage in Mice
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Abstract:
The hepatoprotective effects of flavonoids of Buddleja officinalis Maxim. (L.) DC. (BMF) on CCl4-induced liver damage in mice were studied. The flavonoids extraction was carried out using 70% ethanol. The results showed that BMF extracts at doses 50 and 100 mg/kg/d significantly lowered the levels of serum alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cholinesterase (ChE), lactate dehydrogenase (LDH), total bilirubin (TIBL), and hepatic malondialdehyde (MDA). In addition, the elevated values of liver index and spleen index induced by CCl4 (p<0.05) were suppressed by the BMF extracts. Moreover, the extracts enhanced superoxide dismutase (SOD) activity (p<0.05) and glutathione (GSH) levels (p<0.05) significantly compared to those of the model control group. Furthermore, 50 mg/kg/d BMF showed a stronger effect, which was close to that of silymarin (positive control drug). The results of the histopathological section demonstrated that BMF could mitigate the CCl4-induced damage in the liver tissues, thereby reducing the extent of pathological damage. The protective mechanism of BMF is possibly related to the free radicals scavenging activity and the inhibition of lipid peroxidation.
