Hematopoietic Effect of Fufang Pike Eel Skin Gelatin on Iron Deficiency Anemia
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Abstract:
With the aim of developing a new kind of compound hematopoietic health product, the hematopoietic effect of Fufang pike eel skin gelatin (FEG) on iron deficiency anemia in rats was investigated. The pike eel skin gelatin was prepared using a hot water extraction method, and was combined with Angelica sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Astragalus membranaceus, Radix Polygoni Multiflori Preparata, Fructus Crataegi, and Radix Rehmanniae Preparata. A rat model of iron deficiency anemia (IDA) was established by feeding rats with a traditional low-iron diet and bleeding from the caudal vein. Then, the IDA rats were randomly divided into the following five groups (ten rats per group): model control group, FEG high and low dose groups (FEG-H and FEG-L), and Fufang donkey-hide gelatin high and low dose groups (PC-H and PC-L). After 30 d of administration by gavage, the hematopoietic effect was evaluated by measuring the concentrations of hemoglobin (Hb), serum iron (SI), ferritin (SF), and soluble transferrin receptor (sTfR), and performing red blood cell counts (RBC), hematoxylin and eosin (H & E) staining of liver tissues, and bone marrow smears. The results showed that high dose FEG could significantly improve the value of RBC (p<0.01), reduce the reticulocyte count (p<0.05) and the indices of liver (p<0.01), spleen (p<0.05), and kidney (p<0.01), and alleviate symptoms of bone marrow hyperplasia and liver tissue disorder. Additionally, high dose FEG enhanced Hb content from 77.21 g/L to 175.86 g/L, increased SI and SF concentrations by 2.9 and 0.6 times, respectively, and reduced sTfR concentration by 19.42%. Fufang pike eel skin gelatin could effectively improve the symptoms of IDA.
