Hypoglycemic Effect of Grape Seed Proanthocyanidins in Diabetic Mice
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Abstract:
The hypoglycemic effect of proanthocyanidins was investigated. A diabetic model was established by intraperitoneal injection of streptozotocin (STZ) in mice, and the effect of proanthocyanidins at doses of 50 mg/kg, 100 mg/kg, and 150 mg/kg on the weight of diabetic mice, fasting blood glucose (GLU), glucose tolerance, serum triglyceride (TG), total cholesterol (TC), superoxide dismutase (SOD), lipid peroxide malondialdehyde (MDA), and the concentration of short chain fatty acids was determined. The results revealed that low, medium, and high dose of proanthocyanidins reduced body weight of diabetic mice by 13.23 %，20.85 %, and 30.03 %, respectively; lowered fasting glucose by 10.96 %, 17.18 %, and 20.89 %, respectively, and improved glucose tolerance (p<0.01). High doses of proanthocyanidins effectively decreased serum TC, TG, and MDA by 18.03 %, 32.54 %, and 22.88 %, respectively, while increased the serum SOD activity by 30.28 %. All the three doses of proanthocyanidins significantly increased the levels of total short chain fatty acids (p<0.05 or p<0.01).Thus, proanthocyanidins could reduce the serum sugar level, reduce the free radical damage, inhibit lipid peroxidation, and improve sugar and lipid metabolism in diabetic mice. Proanthocyanidins may play an important role in human health.
