Effects of Konjac Glucomannan and Banana-resistant Starch on Intestinal Secretion of Short-chain Fatty Acids and Blood Lipids in Mice
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Abstract:
A type of prebiotic combining konjac glucomannan (KGM) and banana-resistant starch (BRS) was evaluated, to yield an optimized prebiotic formulation that could maintain and improve intestinal and cardiovascular health. Healthy male BALB/c mice were used as models, and one control group and six experimental groups were established. AIN93 purified diets classified into three groups with different amounts of added BRS and three groups with different proportions of BRS and KGM were designed and fed to the mice. Four weeks later, the cecal short-chain fatty acid (SCFA) levels and blood lipid indices in mice were determined. In the analysis of SCFA levels, the secretion of propionic acid in cecal contents of the mice in group BRS 1, group BRS 2, and group BRS + KGM 2 increased significantly (p < 0.05). Additionally, the secretions of acetic acid, butyric acid, and total SCFAs in group BRS 3 and group BRS + KGM 2 were also significantly increased (p < 0.01), as was butyric acid secretion in group BRS + KGM 3. In the analysis of blood lipid levels, the high-density lipoprotein-cholesterol (HDL-C) levels were significantly increased in group BRS 3 (p < 0.01). In both groups BRS + KGM 2 and BRS + KGM 3, levels of total cholesterol (TC) and triglycerides (TGs) were significantly decreased (p < 0.05 and p < 0.01, respectively), whereas HDL-C levels were significantly increased (p < 0.05). In conclusion, SCFA secretion levels and blood lipid levels were altered in a dose-dependent manner in response to BRS and KGM consumption. The comprehensive comparisons performed in this study revealed that the compound formulation (5% KGM + 23.5% BRS) of group BRS + KGM 2 was the best composite prebiotic formulation.
