Synergistic Anti-aging Effect of Two Types of Probiotic Yogurts Containing Agrocybe aegerita Polysaccharides and Hypsizigus marmoreus Polysaccharides on Skin
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Abstract:
To investigate the synergistic anti-aging effect of probiotic yogurt containing Agrocybe aegerita polysaccharides (AAP) or Hypsizigus marmoreus polysaccharides (HMP) on the skin, D-galactose-induced aging mice were fed two yogurt samples by gavage and the skin tissues were examined by hematoxylin and eosin staining. The results showed that skin lesions occurred in the aging group and that the optimum skin repair effect occurred in the high dose group. Both AAP yogurt and HMP yogurt significantly increased superoxide dismutase activity and moisture content, reduced malondialdehyde content in the mouse skin, and improved hydroxyproline (HYP) content in the tail tendon (P < 0.05); additionally, both samples showed a dose enhancement effect with the amount of added polysaccharides. Compared to the aging model group, the superoxide dismutase activity levels in the mouse skin of the high-dose AAP yogurt and HMP yogurt groups were increased by 66.31% and 14.54%, respectively; moisture content was increased by 16.49% and 8.93%, respectively; HYP content in the skin was increased by 48.27% and 65.59%, respectively; HYP content in the tail tendon was increased by 73.98% and 61.63%, respectively; malondialdehyde content was reduced by 38.96% and 45.64%, respectively. The skin anti-aging indices were significantly improved (P < 0.01). In conclusion, both AAP and HMP polysaccharides have a significant synergistic effect on skin anti-aging activity with probiotic yogurt and can effectively repair damaged skin.
