Effect of Trp on the Intestinal Barrier Function in Pigs
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Abstract:
The intestine is the most important organ in animals. It is not only responsible for the digestion and absorption of nutrients in foods, but also plays an important barrier function. Amino acids play an important role in the intestinal barrier function, intestinal development, and cell proliferation, but the mechanism of tryptophan (Trp) on intestinal barrier and tight junction proteins has not been revealed. In this experiment, healthy growing-finishing pigs were randomly divided into two groups according to body weight: a control group and a 0.2% Trp group. Growth performance, organ index, blood biochemical parameters, intestinal mucosa morphology, intestinal permeability, and the mRNA expression of intestinal tight junction proteins were analyzed. The results showed that tryptophan increased the average daily feed intake and serum diamine oxidase activity, while it reduced the mRNA expression of tight junction proteins, occludin (in the jejunum) and claudin-1 (in the ileum). Thus, to some extent, dietary tryptophan increases the intestinal permeability in growing-finishing pigs.
