Functional Action of a Chinese Herbal Compound in Improving Bowel Movement
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
With development of the social economy and improvement of people’s standard of living, traditional dietary habits have been gradually changing. Consequently, constipation, a common disease affecting quality of life, has attracted considerable attention. Therefore, it is very important to discover safe and effective products that can improve bowel movement. This study aims to evaluate the functional action of a Chinese herbal compound in improving bowel movement. A mouse model of constipation induced using diphenoxylate was used in small intestinal motility and bowel evacuation experiments. Measurements included the first evacuation time, the number of fecal pellets in five hours, the weight of evacuation, the movement rate of ink in the small intestine, and the effect of the herbal compound on colonic substance P (SP), vasoactive intestinal peptide (VIP), and synaptophysin (SY). The results showed that compared with the control group, the groups treated with the Chinese herbal compound exhibited a shortened evacuation time, an increased number of fecal pellets, an increased weight of feces in five hours, an increased movement rate of ink, an enhanced small intestinal movement, an increased SP value, and a decreased VIP level. Therefore, the results demonstrate that the Chinese herbal compound can improve bowel movement in mice.
