Abstract:The effects of Hovenia acerba Lindl. polysaccharides (HAPs) on blood glucose and blood lipids in alloxan (ALX)-induced diabetic mice were investigated in the present study. A mouse model of diabetes was established by intraperitoneal injection of ALX. The ALX-induced diabetic mice were randomly assigned to one of eight groups, including three HAP-treated groups (low-, medium-, and high-doses), a metformin-treated group, a glibenclamide-treated group, an epinephrine-treated group, an untreated diabetic model group, and a normal control group that was not treated with ALX. The HAPs were administered intragastrically for four weeks and the effects of HAPs on the levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were investigated. The HAPs significantly reduced blood glucose in normal rats, markedly mitigated adrenaline-induced hyperglycemia, and effectively reduced serum FBG, HbAlc, TC, and TG, while increasing the concentration of HDL. These results suggest that HAPs can lower blood glucose and improve the metabolic disorders of blood lipids in ALX-induced diabetic mice.
