Protective Effect of Chinese Jujube Vinegar on Alcohol-induced Liver Damage in Mice
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Abstract:
A mouse model of alcoholic liver injury was established by administering alcohol (50%, V/V, 10 mL/kg) to the mice for 42 days, and the protective effect of Chinese jujube vinegar on alcoholic liver injury in mice was studied. The results showed that different doses of Chinese jujube vinegar significantly reduced the activities of aspartate aminotransferase (AST) and alanine transaminase (ALT), concentrations of triglycerides (TG) and total cholesterol (TC) in the serum and lipid peroxidation (LPO) level in the liver of chronic alcohol-intoxicated mice, and the live tissue enlargement was significantly improved. Meanwhile, different doses of Chinese jujube vinegar significantly increased the glutathione (GSH) content and the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and protected the antioxidant system in the liver system of chronically alcohol-intoxicated mice. The results of liver histopathological examination showed that Chinese jujube vinegar may significantly alleviate chronically alcohol-induced liver injury, and the underlying mechanism is related to its inhibitory effect on LPO as well as the enhancement of liver antioxidant enzyme activities and the non-enzymatic antioxidant capacity.
