Anti-lipoperoxidation Effects of Sargassum Fucoidans in Hyperlipidemic Mice
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Abstract:
The effects of four fractions of Sargassum fucoidans (SF) with medium and low molecular weights (MMWF1, MMWF2, LMWF1, and LMWF2) on lipid peroxidation indexes in hyperlipidemic mice were investigated in this study. A mouse model of hyperlipidemia was established. The lipid peroxidation indexes, malondialdehyde (MDA) content, and activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione peroxidase (GSH-PX) in the serum and liver were measured. The results showed that all four SF fractions increased the activities of CAT, GSH-PX, SOD, and POD and decreased the MDA content in the serum and liver at a significant level (p < 0.01) with the high-dose treatments. All four fractions of SF improved anti-oxidation capacity, recovered the balance of the oxidation system, decreased lipid peroxidation, maintained the activity of enzymes related to lipid metabolism, and improved and recovered normal lipid metabolism in hyperlipidemic mice. The anti-lipoperoxidation capacities of the four SF fractions were as follows: MMWF2 > MMWF1 > LMWF2 > LMWF1. The anti-lipoperoxidation capacity of MMWF was greater than that of LMWF, which indicated that among similar fucoidans, increased sulfate content resulted in higher antioxidant capacity.
