Effects of Squid Lecithin on Brain Function of Mice with Scopolamine-induced Dementia
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Abstract:
The effects of squid lecithin (SL) and egg lecithin (EL) on the brain function of mice with dementia induced by scopolamine were comparatively investigated. Male BALB/c mice were randomly divided into 4 groups: control, model, SL (3.3% squid lecithin), and EL groups (1.5% egg lecithin). Mice models were established by intraperitoneal injection of scopolamine a week after feeding, except for the control group mice, which were treated with saline, followed by the behavioral test. Acetylcholinesterase (TchE), superoxide dismutase (SOD), and monoamine oxidase (MAO) activities in the cortex, white matter, and hippocampus, as well as malondialdehyde (MDA) content in the brain were determined. In the Morris water maze test, the latency of mice fed SL significantly reduced, while the number of platform crossings and the time spent in the target quadrant increased significantly; in general, the behavioral improvement of the group fed SL was better than that of the EL group. The biochemical tests of brain tissues also showed similar trends. SL could significantly reduce the TchE activity and MDA level in various brain tissues and MAO activity in white matter, as well as significantly improve the SOD activity in the cortex, hippocampus, and white matter. The results were better than those of the EL group. In summary, SL could improve the learning and memory abilities of mice with dementia by affecting central cholinergic nervous system and antioxidant system in the brain.
