Toxicology of Flavonoid-propionic Acid Mixtures from Banana Peel
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
Crude flavonoid extract was obtained from banana peel by microwave extraction and purified using H103 macroporous resin and combined with propionic acid to produce flavonoid-propionic acid mixtures. Toxicology testing was conducted using these mixtures as per the Procedures for Toxicological Assessment of Food published by Ministry of Health of The People's Republic of China. Toxicology testing included using the acute toxicity test for minimum lethal dose for 50% mice (LD50), bone marrow cell micronucleus test, mice sperm morphology test, and Ames test. The results showed that the LD50 values for female and male mice were 10.8 and 12.6 g/kg body weight (BW), respectively; while the fiducial limits for female and male mice were 7.41~15.7 and 7.75~20.5 g/kg BW, respectively. The results from the acute toxicity test, bone marrow cell micronucleus test, and sperm morphology test were all negative, which implied that flavonoid-propionic acid mixtures from banana peel showed no mutagenic effects on somatic and germ cells and that they did not show indirect or direct mutagenicity. Therefore the mixtures are non-toxic and can be used as preservatives.
