Effect of Different Calcium Supplements on in vitro Acid Consumption and Gastric Acid Secretion in Rats
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Abstract:
Four calcium supplements including calcium citrate malate (CCM), calcium carbonate, yak bone meal, and calcium L-aspartate were administered to rats to compare their effect on gastric secretion as well as gastric acid consumption capacity in rats. The objective of this study was to identify appropriate calcium supplements for human consumption. Using a simulated gastric environment in vitro, the quantity of gastric acid consumed to quench the calcium ions released by the calcium supplements in artificial gastric juice was measured. The effects of calcium supplements on quantity, pH, and secretion of gastric juice were established using the pylorus-ligation rat model. The results showed that the hydrogen ion content increased significantly (p < 0.01) in artificial gastric juice after dissolving CCM, while it decreased significantly (p < 0.05) when the other three calcium supplements were dissolved. In vivo tests in rats showed that, as compared to the control group, the volume, acidity, and secretion of gastric acid decreased significantly (p < 0.01) in the CCM and bone meal groups, increased significantly in the calcium L-aspartate group, and did not show significant difference (p > 0.05) in the calcium carbonate group.
