Protective Effect of Eucalyptus Polyphenols on Acute Ethanol-induced Oxidative Damage in Rats
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Abstract:
To evaluate the protective effect of Eucalyptus polyphenols on acute ethanol-induced oxidative damage in Kunming rats, Eucalyptus leaves were fed to Kunming rats, and a rat model of acute oxidative damage was established by ethanol feeding. The total antioxidant capacities (T-AOC) of the blood and liver, activity of each antioxidant enzyme, and liver tissue lesions of the rats were examined. Eucalyptus polyphenols enhanced the total antioxidant capacity, to a maximum of 33.12% and 56.83% in the serum and liver, respectively. The malondialdehyde (MDA) content was effectively reduced; the largest reductions in the serum and liver were 23.89% and 50.73%, respectively. The total superoxide dismutase (T-SOD) activity was increased to some extent. The glutathione peroxidase (GSH-Px) activity was decreased in the experimental group, but there was no significant difference from the positive control group. The observation of liver slices showed that the cells of three liver tissues from the experimental group were arranged regularly, the number of irregular vacuoles was reduced, and lobular inflammatory cell infiltrations and local necrosis were rarely found, indicating that acute ethanol-induced oxidative damage was inhibited and the liver tissue was protected by Eucalyptus polyphenols. In summary, Eucalyptus polyphenol confers in vivo antioxidant protection, which provides a research basis for the use of Eucalyptus polyphenols as an antioxidant.
