The Separation of Oxyresveratrol from Mulberry Root and Its Effect on Steady-state Embedding and Inhibition of Tyrosinase Activity
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Abstract:
Oxyresveratrol is a 2'-hydroxyl derivative of resveratrol (a trans-stilbene); it is an important natural bioactive product with whitening, anticancer, antioxidant, hepatoprotective, anti-inflammatory, and anti-aging functions. In this study, high-performance liquid chromatography (HPLC) was used to detect oxyresveratrol in mulberry root, and its extraction, separation, steady-state embedding, and inhibitory effects on tyrosinase activity were examined. The extraction rate of oxyresveratrol was 94.32% for the following conditions: 80% ethanol as the extraction solvent, an extraction temperature of 70 ℃, an extraction duration of 1.5 h, a liquid to solid ratio of 4:1, and independent extraction of three times. The steady-state embedding rate of oxyresveratrol was 98.91% for the following conditions: a solid content of 40%, an inlet temperature of 190 ℃, an atomizing disk speed of 16,000 r/min, and a feed speed of 1.78 L/h. The oxyresveratrol standard and oxyresveratrol microcapsule samples both had inhibitory effects on tyrosinase activity, and the strength of inhibition was dose-dependent.
