Protective Effects of Taemyeongcheong against Acetaminophen-induced Hepatic Injury in Mice
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Abstract:
The present study investigated the protective effect of Taemyeongcheong (TMC; Korean traditional beverage) against acetaminophen (APAP)-induced liver damage in mice. ICR mice were administrated low dose (100 mg/kg), medium dose (250 mg/kg), and high dose (500 mg/kg) TMC as well as silymarin (S; positive control) by gavage for 14 consecutive days. An animal model of acute liver failure was established by intraperitoneal injection of APAP (800 mg/kg) in mice. After the mice were euthanized, their blood and organs were collected and measured for each indicator of hepatic injury. Compared with the control group, the indicators of hepatic injury for TMC group were significantly lower. All three doses of TMC could significantly reduce the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglycerides (TG), and blood urea nitrogen (BUN), and increase the levels of total cholesterol (TC) and albumin (ALB) (p < 0.05). In addition, a dose-effect relationship was observed with the three doses, among which the high dose TMC group showed a significant protective effect against hepatic injury and ranked second to the positive control, silymarin group (p < 0.05). According to the liver pathological images, inflammation and liver cell necrosis were significantly reduced in TMC group compared with the control group. Therefore, TMC had a moderate protective effect on APAP-induced liver damage in mice.
