Mechanism of Inhibition by Polypeptide from Bay Scallop of H22 Hepatocarcinoma Transplanted into Mice
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Abstract:
The aim of this study was to explore the inhibitory effect and the underlying mechanism of inhibition by polypeptide from bay scallop (PBS) on H22 hepatocarcinoma transplanted in mice. A total of 50 Kunming (KM) mice were randomly divided into normal control group, H22 hepatocarcinoma model group, low-dose PBS (500 mg/kg?bw) group, medium-dose PBS (1000 mg/kg?bw) group, and high-dose PBS (1500 mg/kg?bw) group. An in vivo gavage experiment was performed. The results showed that the tumor inhibition rate in low-, medium-, and high-dose groups were 28.16%, 41.93%, and 84.00%, respectively, showing a dose-dependent effect. Compared to the model group, serum levels of mutant p53, survivin, 8-iso-prostaglandin F2α (PGF2α), and malondialdehyde (MDA) in the three PBS groups showed a decrease, while that of interleukin-2, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and tumor necrosis factor-α showed an increase. Additionally, the effect seen in the medium-dose group was more obvious than that in the other two groups. The same trend was found in the liver extracts from the three dose groups. Pathological evaluations also showed visible antitumor effects by PBS. Thus, this study indicated that PBS exerts obvious inhibitory effects on mouse H22 hepatocarcinoma cells.
