Regulation of Lipid Metabolism and Oxidative Stress by Bamboo Leaf Flavonoid and Cassia Seed Compound Associated with Ascorbyl Palmitate and Vitamin E Succinate in Hyperlipidemia Rats
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Abstract:
This study was to investigate the in vitro oxidative stress activity of bamboo leaf flavonoid (BLF) and Cassia seed powder (CSF) compound (16:9, m/m), in combination with ascorbyl palmitate (AP) and Vitamin E succinate (α-TOS), as well as their ability to regulate lipid metabolism and anti-oxidative stress at different ratios in hyperlipidemic rats. Combination of [BLF +CSF] and AP with ratio of 5:1) had synergistic anti-oxidative activity, which was significantly higher than that of [BLF+CSF] and α-TOS with ratio of5:1. The combination of [BLF+CSF], AP, and α-TOS with ratio of 5:1:1 exhibited the most significant synergistic effect. A hyperlipidemia rat model was established, and the lipid-lowering and anti-oxidant abilities of different combinations were evaluated. The results showed that all combinations could effectively regulate lipid metabolism and reduce oxidative stress in hyperlipidemic rats. The combination of [BLF+CSF], AP, and α-TOS (5:1:1) had the strongest synergistic effect in regulating lipid metabolism and oxidative stress. The synergistic effect included a significant reduction in atherosclerosis index and regulation of blood lipids. Total cholesterol (p < 0.01), triglycerides (p < 0.01), and low density lipoprotein cholesterol (p < 0.01) were reduced, and high density lipoprotein cholesterol was increased (p < 0.01). In terms of oxidative stress, the combination significantly increased serum total antioxidant capacity (p < 0.01), superoxide dismutase activity (p < 0.01), and glutathione peroxidase activity (p < 0.01), and reduced malondialdehyde content (p < 0.01).
