Effect of Inclusion of 4-Hydroxychalcone in Hydroxypropyl-β-Cyclodextrin
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Abstract:
In order to study the inclusion mechanism of the complex of hydroxypropyl-β-cyclodextrin (HP-β-CD) and chalcone, the thermodynamic parameters of the inclusion process of β-CD, HP-β-CD and 4-hydroxychalcone were measured by phase solubility study. And the physicochemical properties of the complex were investigated by infrared spectrometry (IR), X-ray diffractometry (XRD) and thermogravimetric/differential scanning calorimetry (TG/DSC). It was found the inclusion effect of HP-β-CD on 4-hydroxychalcone was higher than that of β-CD. And the Gibbs energy values were negative for the formation of the complex of HP-β-CD and 4-hydroxychalcone. And the inclusion was a spontaneous process, which was driven by hydrophobic force. IR and XRD analysis showed that the physical phase of 4-hydroxylchalcone had been changed, which were completely dispersed in HP-β-CD. TG/DSC analysis found the heat stability of 4-hydroxychalcone had been significantly enhanced by complexing with HP-β-CD.
