Synthesis of Dihydromyricetin-theanine Complex and Its Antioxidant Activity
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Abstract:
Dihydromyricetin is currently attracting extensive scientific attention because of its various physiological functions. Although the content of dihydromyricetin in Ampelopsis grossedentata is up to 25.6%, its poor water solubility at room temperature and low bioavailability limit the scope of its application. In order to improve the water solubility of dihydromyricetin, its structure was modified and a dihydromyricetin-theanine complex was prepared. The structure was characterized by UV, IR, MS, and 1HNMR spectra, its physical and chemical properties were measured, and the antioxidant activity of the complex was investigated. Based on structural analysis, the complex was found to be formed via hydrogen bonding interactions between C3-OH, C5-OH, C7-OH, C3'-OH, and C5'-OH in dihydromyricetin and active hydrogens in theanine. The scavenging capacity of the complex against hydroxyl free radicals was stronger than that of dihydromyricetin and Vc, and was equivalent to that of dihydromyricetin against superoxide and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, but was better than that of Vc. It is therefore considered that the complexation of dihydromyricetin with theanine not only improved the water solubility of dihydromyricetin but also enhanced its antioxidant activity.
