Performance Study on Microemulsion Lyophilized Powder of Evening Primrose Oil
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Abstract:
To investigate the effects of cryoprotectants on the freeze-drying of evening primrose oil microemulsion and its stability, the distribution of Sudan II in the lyophilized powder was analyzed by differential scanning calorimeter (DSC). The cryoprotectants for the microemulsion were screened in terms of appearance, size and powder disperse ability. The stability of the powder under various conditions of storage time and temperature was investigated with the entrapment efficiency as the observing index. In summary, mannitol was shown to be the best cryoprotectant. The lyophilized powder showed good granular pattern, dispersion speed, and large-sized particles. After storage for six months, the entrapment efficiency was decreased from 90.92% to 82.58±0.66% at 37 ℃; while it only decreased to 89.50% and 88.80 it on at 4 ℃ and 20 ℃, respectively. DSC results showed that Sudan II had no effect on thermal property of the microemulsion lyophilized powder and existed as amorphous pattern. The microemulsion lyophilized powder, prepared using evening primrose oil as the oily phase and mannitol as the lyoprotectant, was stable, with high entrapment efficiency and no significant change after stored for 6 months.
