Effect of Polysaccharides from Wild Jujube on Acute Liver Injury Induced by CCl4 in Mice
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Abstract:
Polysaccharides from wild jujube (PWJS) were isolated by distilled water extraction and its anti-oxidative activity and liver protection capability were investigated. Acute injury models were set by CCl4 in mice and ALT, AST activities in serum, CAT, SOD activities, MDA content in liver homogenates were tested by biochemical assays. Liver tissue of the mice was stained with hematoxylin-eosin (HE) for observing the effect of PWJS on mice liver histopathology. Results showed that PWJS had strong antioxidant ability in vitro. Meanwhile, in vivo study showed that, compared with model group, ALT and ALP activities in serum declined significantly and the maximal decline rate was 34.33%. CAT, SOD activities in liver homogenates significantly increased, with the maximum increasing rate being 35.88%. MDA content in liver homogenates declined significantly and the maximal decline rate was high to 52.07%. Thus, PWJS successfully reduce hepatotoxicity in CCl4-induced liver injury mice, due to the regulation of serum enzymes and antioxidant enzymes activity.
