Immunological Effects of Schizophyllum commune Polysaccharides in Mice
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Abstract:
In this study, polysaccharide from Schizophyllum commune was obtained by ultrasound-assisted water extraction and an immunocompromised mouse model was established by intraperitoneal injection of cyclophosphamide. Immunological effects of different doses of S. commune polysaccharides administered to mice intragastrically were investigated in terms of non-specific immunity, cell-mediated immunity, and humoral immunity. The inhibitory effects of S. commune polysaccharides on the in vitro proliferation of mouse macrophages and colon carcinoma were evaluated by MTT assay. The results showed that S. commune polysaccharides had a certain recovery effect on the thymus and spleen as well as caused sensitization in mice injected with sheep red blood cells in their footpads, leading to swelling. In mice injected with different doses of S. commune polysaccharides, serum levels of hemolysin, IgG, IgA, and IL-2 increased to varying degrees as compared to the immunocompromised mice group. In addition, S. commune polysaccharides could increase phagocytosis by murine macrophages and at 2000 μg/mL concentration, showed up to 45.32% inhibition of colon carcinoma cells.
