In vivo Antitumor Activity of the Active Protein Components from Agrocybe aegerita on Tumor-bearing Mouse Model
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Abstract:
The regulation effect of active antitumor protein components Yt from macrofungi Agrocybe aegerita on immune system were investigated in this research. The antitumor activity, the antibody titer, and the immune memory effect were detected on H22-bearing mouse model treated by intratumoral injection of Yt (5 mg/kg). The alteration expression of serum cytokines IL-2 and TNF-α was also measured by ELISA. The results showed that Yt significantly inhibited the tumor growth. The treatment of Yt, the protein component Yp, and the low weight molecules component Ys did not induce the production of high titer antibody and result in toxicity. Yt induced the long-term memory effect to protect the animals from the tumor cell challenge, up-regulated the expression of serum IL-2 (84.6±37.6 pg/mL, p<0.05), and did not significantly change the expression of TNF-α. All these data indicated that Yt could active the immune system, and thus can be potentially used as the immune adjuvant of tumor vaccine.
